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Clinical Trials

Diabetic Retinopathy

Active Studies

ALTITUDE (RegenxBio)

A Phase 2, Randomized, Dose-escalation, Observation-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of RGX-314 Gene Therapy Delivered via a Single Suprachoroidal Space (SCS) Injection in Participants with Diabetic Retinopathy (DR) Without Center Involved-Diabetic Macular Edema (CI-DME).

LTFU NPDR (RegenxBio)

A Long-term Follow-Up Study to Evaluate the Safety and Efficacy of Suprachoroidal Administration of RGX-314 for Diabetic Retinopathy Without Center Involved-Diabetic Macular Edema.

Completed Studies

Cystoid Macular Edema after Cataract Surgery (Allergan)

Phase 2 Study of the Dexamethasone Intravitreal Implant (Ozurdex) for combined Pseudophakic Cystoid Edema and Diabetic Macular Edema after cataract surgery.

DA VINCI (Regeneron)

Phase 2 study of the safety, tolerability and biological effect of repeated aflibercept (Eylea) in diabetic macular edema.

DEGAS (Pfizer)

Phase 2 study of the efficacy and safety of PF-04523655 versus laser in diabetic macular edema.

PACIFIC (Allegro)

A 6 month, phase 2, randomized, double-masked, placebo-controlled multicenter clinical trial designed to evaluate the safety and efficacy of Luminate in inducing PVD in subjects with non-proliferative diabetic retinopathy.

PANORAMA (Regeneron)

A 2 year, Phase 3, multicenter, randomized study of the efficacy and safety of intravitreal aflibercept (Eylea) injection in patients with moderately severe to severe nonproliferative diabetic retinopathy.

RIDE (Genentech)

Phase 3 study of the efficacy and safety of Ranibizumab (Lucentis) in diabetic macular edema.


Phase 2 Spectra study to evaluate the safety and efficacy of OPL-0401 in patients with diabetic retinopathy

VISTA (Regeneron)

A 3 year Phase 3 study of the efficacy, safety and tolerability of aflibercept (Eylea) in patients with diabetic macular edema.